The Six Minute Walk Distance ( 6 Mwd ) - 847 Words

Galie’s et al. compared the six-minute walk distance (6-MWD) in patients twelve years or older with symptomatic pulmonary arterial hypertension (PAH) who took placebo versus 4 doses of oral tadalafil with or without bosentan. This multi-center, double-blind, placebo-controlled, randomized controlled study lasted 16 weeks. The patients were placed into 5 different groups: tadalafil 2.5mg, 10mg, 20mg, 40mg, or placebo once daily, and stratification was based on walking distance of 325m, type of PAH, and bosentan use. Patients were not qualified to participate in this study if they had a 6-mintue walk distance 150m or 450m. Safety was determined by the level of adverse events severity. It was shown that all doses, but 2.5mg, improved 6-MWD at week 16, although, the tadalafil 40mg was the only one that was statistically significant (p0.01). Compared with placebo, tadalafil 40mg had statistical significance of 6-MWD without bosentan therapy at 44m, versus patients with bosentan wi th a 6-MWD of 23m. The WHO functional class was not statistically significant in comparison with placebo because patients with better WHO functional class showed no difference in comparison to people with worse WHO functional class. After the 341 patients completed the 16 week trial, 334 of them accepted participation in another 16 week trial. Their 6-MWD slightly improved from 37m to 38m after 44 weeks, which was shown to be statistically significant (95% CI, 29 to 47). In addition, WHO functionalShow MoreRelatedSecurity Forces51988 Words   |  208 Pages(TECH. TRNG.) STUDY GUIDE (SG) L3ABR3P031 0S1C SECURITY FORCES STUDY GUIDE (SG L3ABR3PO31 OS1C) DESIGNED TO ENHANCE FORMAL CLASSROOM TRAINING AREA INSTRUCTION BLOCK IV TABLE OF CONTENTS UNIT Unit 1 Unit 2 Unit 3 Unit 4 Unit 5 Unit 6 Unit 7 Unit 8 Unit 9 Unit 10 Unit 11 Unit 12 Unit 13 Unit 14 Unit 15 Unit 16 Acronyms TITLE Defense Concepts Threats and Detection Random Antiterrorism Measures Communications Fire Control Measures Field Considerations Captives, Detainees, and PrisonersRead More1000 Word Essay85965 Words   |  344 Pagesnumber of months necessary to permit completion. (AR 600-85 Mar 2006 / 5-6 / PDF 31) Will Soldiers who are command referred to ASAP be flagged? Yes, IAW AR600-8-2 (Suspension of Favorable Personnel Action (flags)). (AR 600-85 Mar 2006 / 5-7 / PDF 31) What Does ACS stand for? Army Community Service (AR 608-1 Dec 2004) What does the ACS symbol represent? The heart = giving, the cross = help, the gyroscope = stability Page 6 / 389  © Copyright 1999-2012 ArmyStudyGuide.com Version 5.3 (AR 608-1